Persistence of viral RNA in the brain of offspring to mice infected with inuenza A/WSN/33 virus during pregnancy
نویسندگان
چکیده
Epidemiological studies have indicated an association between inuenza A virus infections during fetal life and neuropsychiatric diseases. To study the potential for inuenza A virus infections to cause nervous system dysfunctions, we describe a mouse model using intranasal instillation of the mouse neuroadapted inuenza A/WSN/33 strain in pregnant mice. Viral RNA and nucleoproteinwere detected in fetal brains and the viral RNApersisted for at least 90 days of postnatal life. We have, thus, obtained evidence for transplacental passage of inuenza virus in mice and the persistence of viral components in the brains of these animals into young adulthood. Journal of NeuroVirology (2002) 8, 353–357.
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Persistence of the inuenza A/WSN/33 virus RNA at midbrain levels of immunodefective mice
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